Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation.

@article{Benyon1999ProgelatinaseAI,
  title={Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation.},
  author={Robert Christopher Benyon and Christopher J Hovell and M Da Gaça and Elizabeth H. Jones and John Peter Iredale and Michael J P Arthur},
  journal={Hepatology},
  year={1999},
  volume={30 4},
  pages={977-86}
}
Activated hepatic stellate cells (HSCs) are a potential source of gelatinase A, which accumulates in fibrotic livers. Progelatinase A activation requires its binding to a complex of membrane-type matrix metalloproteinase (MT-MMP) and tissue inhibitor of metalloproteinases (TIMP)-2. These studies examine gelatinase A, MT1-MMP, and TIMP-2 synthesis by HSCs during activation in vitro and the potential role of gelatinase A in promoting HSC proliferation. Gelatinase A, MT1-MMP, and TIMP-2 messenger… CONTINUE READING
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