Progastrin1-80 stimulates growth of intestinal epithelial cells in vitro via high-affinity binding sites.

@article{Singh2003Progastrin180SG,
  title={Progastrin1-80 stimulates growth of intestinal epithelial cells in vitro via high-affinity binding sites.},
  author={Pomila Singh and Xinping Lu and Stephanie Cobb and Bradford T. Miller and Nadya Tarasova and Andrea Varr{\'o} and Azarmidokht Owlia},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2003},
  volume={284 2},
  pages={G328-39}
}
Proliferation and carcinogenesis of the large intestinal epithelial cells (IEC) cells is significantly increased in transgenic mice that overexpress the precursor progastrin (PG) peptide. It is not known if the in vivo growth effects of PG on IEC cells are mediated directly or indirectly. Full-length recombinant human PG (rhPG(1-80)) was generated to examine possible direct effects of PG on IEC cells. Surprisingly, rhPG (0.1-1.0 nM) was more effective than the completely processed gastrin 17… CONTINUE READING
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