Progastrin and Cyclooxygenase-2 in Colorectal Cancer

  title={Progastrin and Cyclooxygenase-2 in Colorectal Cancer},
  author={Peter Christopher Konturek and Władysław Bielański and Stanisław Jan Konturek and Artur Hartwich and Piotr Pierzchalski and Macien Gonciarz and Krzysztof Marlicz and Teresa Starzyńska and Monika Żuchowicz and Zbigniew Darasz and Jens Peter Goetze and Jens Frederik Rehfeld and Eckhart Georg Hahn},
  journal={Digestive Diseases and Sciences},
Colorectal cancers (CRCs) are one of the most common forms of cancer in Poland and one of the leading causes of death. The tumors have been attributed to genetic, dietary, and other environmental factors, but recently growth factors such as gastrin have also been implicated in the carcinogenesis. The relationship between plasma amidated and nonamidated gastrin in CRCs is controversial. This study was designed (1) to determine the plasma levels of progastrin and amidated gastrin in 50 CRC… CONTINUE READING


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