Profound reduction in sensitivity to the aversive effects of methamphetamine in mice bred for high methamphetamine intake.

@article{Shabani2012ProfoundRI,
  title={Profound reduction in sensitivity to the aversive effects of methamphetamine in mice bred for high methamphetamine intake.},
  author={Shkelzen Shabani and Carrie S. McKinnon and Christopher L. Cunningham and Tamara J Phillips},
  journal={Neuropharmacology},
  year={2012},
  volume={62 2},
  pages={1134-41}
}
Reduced sensitivity to aversive effects of methamphetamine (MA) may increase risk for MA abuse. Studies in two replicate sets of mouse lines that were selectively bred for high and low levels of MA intake support this view. Current studies examined the extent of insensitivity to aversive MA effects of mice bred for high levels of MA drinking. Conditioning procedures in which drugs are delivered shortly after cue exposure have been used to detect aversive drug effects and, in some cases, are… CONTINUE READING

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