Profound platelet degranulation is an important side effect of some types of contrast media used in interventional cardiology.

@article{Chronos1993ProfoundPD,
  title={Profound platelet degranulation is an important side effect of some types of contrast media used in interventional cardiology.},
  author={Nicolas A F Chronos and Alison H. Goodall and Darren J. Wilson and Ulrich Sigwart and Nigel P. Buller},
  journal={Circulation},
  year={1993},
  volume={88 5 Pt 1},
  pages={2035-44}
}
BACKGROUND Thrombotic complications occurring during coronary angiography and percutaneous transluminal coronary angioplasty (PTCA) are relatively frequent and can be influenced by the type of radiographic contrast media used. Low osmolar contrast media (LOCM), both ionic and nonionic, have been considered to be safer than the older high osmolar contrast media (HOCM), causing less haemodynamic and symptomatic side effects. Recently, however, nonionic LOCM have been associated with an increased… CONTINUE READING

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