Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease.

@article{GmezIsla1996ProfoundLO,
  title={Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease.},
  author={Teresa G{\'o}mez-Isla and Joseph L. Price and D Mckeel and John C. Morris and John Growdon and Bradley T. Hyman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1996},
  volume={16 14},
  pages={4491-500}
}
The entorhinal cortex (EC) plays a crucial role as a gateway connecting the neocortex and the hippocampal formation. Layer II of the EC gives rise to the perforant pathway, the major source of the excitatory input to the hippocampus, and layer IV receives a major hippocampal efferent projection. The EC is affected severely in Alzheimer disease (AD), likely contributing to memory impairment. We applied stereological principles of neuron counting to determine whether neuronal loss occurs in the… CONTINUE READING
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