Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis

@article{Rochman2017ProfoundLO,
  title={Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis},
  author={Mark Rochman and Jared Travers and Cora E Miracle and Mary C Bedard and Ting Wen and Nurit P Azouz and Julie M Caldwell and Kiran Kumar Kc and Joseph D. Sherrill and Benjamin P Davis and Jeffrey K. Rymer and Kenneth M Kaufman and Bruce J. Aronow and Marc E. Rothenberg},
  journal={The Journal of Allergy and Clinical Immunology},
  year={2017},
  volume={140},
  pages={738–749.e3}
}
  • Mark Rochman, Jared Travers, +11 authors Marc E. Rothenberg
  • Published in
    The Journal of allergy and…
    2017
  • Medicine
  • The Journal of Allergy and Clinical Immunology
  • Background A key question in the allergy field is to understand how tissue‐specific disease is manifested. Eosinophilic esophagitis (EoE) is an emerging tissue‐specific allergic disease with an unclear pathogenesis. Objective Herein we tested the hypothesis that a defect in tissue‐specific esophageal genes is an integral part of EoE pathogenesis. Methods We interrogated the pattern of expression of esophagus‐specific signature genes derived from the Human Protein Atlas in the EoE transcriptome… CONTINUE READING

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