Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement.

Abstract

The value of rewards (natural rewards and drugs) is associated with dopamine increases in the nucleus accumbens and varies as a function of context. The prefrontal cortex has been implicated in the context dependency of rewards and in the fixated high value that drugs have in addiction, although the mechanisms are not properly understood. Here we test the… (More)

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