Profound, Non-Opioid Analgesia Produced by the High-Efficacy 5-HT1A Agonist F 13640 in the Formalin Model of Tonic Nociceptive Pain

@article{Bardin2003ProfoundNA,
  title={Profound, Non-Opioid Analgesia Produced by the High-Efficacy 5-HT1A Agonist F 13640 in the Formalin Model of Tonic Nociceptive Pain},
  author={Laurent Bardin and J. P. Tarayre and N. Malfetes and Wouter Koek and F. C. Colpaert},
  journal={Pharmacology},
  year={2003},
  volume={67},
  pages={182 - 194}
}
Previously, we have reported that in rat models of chronic pain, in particular, the very-high-efficacy 5-HT1A agonist F 13640 induces unprecedented pain relief by novel neuroadaptative mechanisms that involve inverse tolerance and cooperation with nociceptive stimulation in producing analgesia. The present studies detailed the actions of F 13640 and other compounds in the formalin model of tonic nociceptive pain. Intraperitoneal injection of F 13640 (0.01–2.5 mg/kg; t –15 min) caused a dose… 

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