Profiling tissue-resident T cell repertoires by RNA sequencing

@inproceedings{Brown2015ProfilingTT,
  title={Profiling tissue-resident T cell repertoires by RNA sequencing},
  author={Scott D. Brown and Lisa Ann Raeburn and Robert A. Holt},
  booktitle={Genome Medicine},
  year={2015}
}
Deep sequencing of recombined T cell receptor (TCR) genes and transcripts has provided a view of T cell repertoire diversity at an unprecedented resolution. Beyond profiling peripheral blood, analysis of tissue-resident T cells provides further insight into immune-related diseases. We describe the extraction of TCR sequence information directly from RNA-sequencing data from 6738 tumor and 604 control tissues, with a typical yield of 1 TCR per 10 million reads. This method circumvents the need… CONTINUE READING

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