Profiling the relationship between tumor-associated macrophages and pharmacokinetics of liposomal agents in preclinical murine models.

@article{Lucas2017ProfilingTR,
  title={Profiling the relationship between tumor-associated macrophages and pharmacokinetics of liposomal agents in preclinical murine models.},
  author={Andrew Thomas Lucas and Taylor F. White and Allison M Deal and Leah B Herity and Gina Song and C Santos and William C. Zamboni},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  year={2017},
  volume={13 2},
  pages={
          471-482
        }
}
The mononuclear phagocyte system (MPS) has previously been shown to significantly affect the clearance, tumor delivery, and efficacy of nanoparticles (NPs). This study profiled MPS cell infiltration in murine preclinical tumor models and evaluated how these differences may affect tumor disposition of PEGylated liposomal doxorubicin (PLD) in models sensitive and resistant to PLD. Significant differences in MPS presence existed between tumor types (e.g. ovarian versus endometrial), cell lines… CONTINUE READING

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