Profiling the RNA editomes of wild-type C. elegans and ADAR mutants.

  title={Profiling the RNA editomes of wild-type C. elegans and ADAR mutants.},
  author={Han-Qing Zhao and Pan Zhang and Hua Gao and Xiandong He and Yanmei Dou and August Yue Huang and X. G. Liu and Adam Y. Ye and Meng-Qiu Dong and Liping Wei},
  journal={Genome research},
  volume={25 1},
RNA editing increases transcriptome diversity through post-transcriptional modifications of RNA. Adenosine deaminases that act on RNA (ADARs) catalyze the adenosine-to-inosine (A-to-I) conversion, the most common type of RNA editing in higher eukaryotes. Caenorhabditis elegans has two ADARs, ADR-1 and ADR-2, but their functions remain unclear. Here, we profiled the RNA editomes of C. elegans at different developmental stages of wild-type and ADAR mutants. We developed a new computational… CONTINUE READING
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