Profiling of renal tubule Na+ transporter abundances in NHE3 and NCC null mice using targeted proteomics.

@article{Brooks2001ProfilingOR,
  title={Profiling of renal tubule Na+ transporter abundances in NHE3 and NCC null mice using targeted proteomics.},
  author={Heddwen L. Brooks and Ann M. Sorensen and Jane Terris and Patrick J. Schultheis and John N. Lorenz and Gary E. Shull and Mark A. Knepper},
  journal={The Journal of physiology},
  year={2001},
  volume={530 Pt 3},
  pages={359-66}
}
The Na+-H+ exchanger NHE3 and the thiazide-sensitive Na+-Cl- cotransporter NCC are the major apical sodium transporters in the proximal convoluted tubule and the distal convoluted tubule of the kidney, respectively. We investigated the mechanism of compensation that allows maintenance of sodium balance in NHE3 knockout mice and in NCC knockout mice. We used a so-called 'targeted proteomics' approach, which profiles the entire renal tubule with regard to changes in Na+ transporter and aquaporin… CONTINUE READING

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