Profiling of energy metabolism in olanzapine-induced weight gain in rats and its prevention by the CB1-antagonist AVE1625.

@article{Liebig2010ProfilingOE,
  title={Profiling of energy metabolism in olanzapine-induced weight gain in rats and its prevention by the CB1-antagonist AVE1625.},
  author={Michaela Liebig and Matthias Gossel and Jeremy Pratt and Mark Black and Guido Haschke and Ralf Elvert and H J Juretschke and Claudia Neumann-Haefelin and Werner Kramer and Andreas Waldemar Herling},
  journal={Obesity},
  year={2010},
  volume={18 10},
  pages={1952-8}
}
This is the first study to examine the effect of subchronic olanzapine (OLZ) on energy homeostasis in rats, covering all aspects of energy balance, including energy intake as metabolizable energy, storage, and expenditure. We further analyzed whether, and by which mechanism, the CB1-antagonist AVE1625 might attenuate OLZ-induced body weight gain. For this purpose, we selected juvenile female Hanover Wistar rats that robustly and reproducibly demonstrated weight gain on OLZ treatment, accepting… CONTINUE READING
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intervention on body weight and body composition of obese psychiatric patients taking olanzapine

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