Profiling of Parkin-Binding Partners Using Tandem Affinity Purification

  title={Profiling of Parkin-Binding Partners Using Tandem Affinity Purification},
  author={Alessandra Zanon and Aleksandar Rakovic and Hagen Blankenburg and Nadezhda T. Doncheva and Christine Schwienbacher and Alice Serafin and Adrian Alexa and Christian X Weichenberger and Mario Albrecht and Christine Klein and Andrew A Hicks and Peter P. Pramstaller and Francisco S. Domingues and Irene Pichler},
  booktitle={PloS one},
Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting approximately 1-2% of the general population over age 60. It is characterized by a rather selective loss of dopaminergic neurons in the substantia nigra and the presence of α-synuclein-enriched Lewy body inclusions. Mutations in the Parkin gene (PARK2) are the major cause of autosomal recessive early-onset parkinsonism. The Parkin protein is an E3 ubiquitin ligase with various cellular functions, including the… CONTINUE READING
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