Profiling of FSHR negative allosteric modulators on LH/CGR reveals biased antagonism with implications in steroidogenesis

@article{Ayoub2016ProfilingOF,
  title={Profiling of FSHR negative allosteric modulators on LH/CGR reveals biased antagonism with implications in steroidogenesis},
  author={Mohammed Akli Ayoub and Romain Yvinec and Gwenhael J{\'e}got and James A. Dias and Sonia Maria Poli and Anne Poupon and Pascale Cr{\'e}pieux and Eric Reiter},
  journal={Molecular and Cellular Endocrinology},
  year={2016},
  volume={436},
  pages={10-22}
}
Biased signaling has recently emerged as an interesting means to modulate the function of many G protein-coupled receptors (GPCRs). Previous studies reported two negative allosteric modulators (NAMs) of follicle-stimulating hormone receptor (FSHR), ADX68692 and ADX68693, with differential effects on FSHR-mediated steroidogenesis and ovulation. In this study, we attempted to pharmacologically profile these NAMs on the closely related luteinizing hormone/chorionic gonadotropin hormone receptor… Expand
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