Profiling of CD4+ T cells with epigenetic immune lineage analysis.

@article{Janson2011ProfilingOC,
  title={Profiling of CD4+ T cells with epigenetic immune lineage analysis.},
  author={Peter C. J. Janson and Ludvig Bernt Linton and Emma Ahl{\'e}n Bergman and Per Marits and M Eberhardson and Fredrik Piehl and Vivianne Malmstr{\"o}m and Ola Winqvist},
  journal={Journal of immunology},
  year={2011},
  volume={186 1},
  pages={
          92-102
        }
}
Proper transcriptional control of pro- and anti-inflammatory responses of the immune system is important for a fine-tuned balance between protection and tolerance. Emerging evidence suggests a key role for epigenetic regulation in governing the Th cell differentiation, where effector cytokines direct the overall immune response. In this study, we describe a method to pinpoint the location of isolated human CD4(+) T cells on any T cell effector axis based on specific CpG methylation of cytokine… CONTINUE READING
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