Profiling mitochondrial proteins in radiation-induced genome-unstable cell lines with persistent oxidative stress by mass spectrometry.

@article{Miller2008ProfilingMP,
  title={Profiling mitochondrial proteins in radiation-induced genome-unstable cell lines with persistent oxidative stress by mass spectrometry.},
  author={John H Miller and Shunqian Jin and William F. Morgan and Aifeng Yang and Youzhong Wan and Umut Aypar and Julian S Peters and D. L. Springer},
  journal={Radiation research},
  year={2008},
  volume={169 6},
  pages={700-6}
}
Previous work by Morgan and coworkers on radiation-induced genome instability in Chinese hamster ovary (CHO) cell lines showed that unstable LS-12 cells had persistently elevated levels of reactive oxygen species (ROS) that were likely due to dysfunctional mitochondria. To further investigate the correlation between radiation-induced genome instability and dysfunctional mitochondria, we performed quantitative high-throughput mass spectrometry on samples enriched in mitochondrial proteins from… CONTINUE READING

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