Profiling mitochondrial complex I inhibitors by combining mitochondrial morphological features and maximum common chemical substructures

Abstract

Studies on the mechanism of toxins are important to reveal the etiology of Parkinson's disease (PD). Complex I inhibitors are a main group of PD toxins, and their chemical features have been intensively studied. However, the chemical structures specific to mitochondrial morphological changes are still unknown. We developed a drug profiling system that… (More)

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