Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation

@inproceedings{Cheng2014ProfilingAT,
  title={Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation},
  author={Genhong Cheng and Joanna Zielonka and Donna M. McAllister and Susan S. Tsai and Michael B. Dwinell and Balaraman Kalyanaraman},
  booktitle={British Journal of Cancer},
  year={2014}
}
Background:Targeting both mitochondrial bioenergetics and glycolysis pathway is an effective way to inhibit proliferation of tumour cells, including those that are resistant to conventional chemotherapeutics.Methods:In this study, using the Seahorse 96-well Extracellular Flux Analyzer, we mapped the two intrinsic cellular bioenergetic parameters, oxygen consumption rate and proton production rate in six different pancreatic cancer cell lines and determined their differential sensitivity to… CONTINUE READING

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