Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples

  title={Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples},
  author={Laura E Macconaill and Catarina D. Campbell and Sarah M. Kehoe and Adam J. Bass and Charles Hatton and Lili Niu and Matt Davis and Keluo Yao and Megan C. Hanna and Chandrani Mondal and Lauren A Luongo and Caroline M. Emery and Alissa C. Baker and Juliet Philips and Deborah J. Goff and Michelangelo Fiorentino and Mark A. Rubin and Korn{\'e}lia Poly{\'a}k and Jennifer Chan and Yue-Xiang Wang and Jonathan Alfred Fletcher and Sandro S. Santagata and Gianni Corso and Franco Roviello and Ramesh A. Shivdasani and Mark W Kieran and Keith L Ligon and Charles Dean Stiles and William C. Hahn and Matthew L Meyerson and Levi A. Garraway},
  booktitle={PloS one},
BACKGROUND Detection of critical cancer gene mutations in clinical tumor specimens may predict patient outcomes and inform treatment options; however, high-throughput mutation profiling remains underdeveloped as a diagnostic approach. We report the implementation of a genotyping and validation algorithm that enables robust tumor mutation profiling in the clinical setting. METHODOLOGY We developed and implemented an optimized mutation profiling platform ("OncoMap") to interrogate approximately… CONTINUE READING
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Phase I study of PLX 4032 : Proof of concept for V 600 E BRAF mutation as a therapeutic target in human cancer

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