Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy.

  title={Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy.},
  author={Viola Kooij and M. Viswanathan and Dong ik Lee and Peter P Rainer and William Lamborn Schmidt and William A. Kronert and Sian E Harding and David A. Kass and Sanford I Bernstein and Jennifer E. van Eyk and Anthony Cammarato},
  journal={Cardiovascular research},
  volume={110 2},
AIMS Heart failure is often preceded by cardiac hypertrophy, which is characterized by increased cell size, altered protein abundance, and actin cytoskeletal reorganization. Profilin is a well-conserved, ubiquitously expressed, multifunctional actin-binding protein, and its role in cardiomyocytes is largely unknown. Given its involvement in vascular hypertrophy, we aimed to test the hypothesis that profilin-1 is a key mediator of cardiomyocyte-specific hypertrophic remodelling. METHODS AND… CONTINUE READING
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