Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri.

@article{Mimuro2000ProfilinIR,
  title={Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri.},
  author={Hitomi Mimuro and Tadaki Suzuki and Shiro Suetsugu and Hiroaki Miki and Tadaomi Takenawa and Chihiro Sasakawa},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 37},
  pages={28893-901}
}
The ability of Shigella to mediate actin-based motility within the host cell is a prominent pathogenic feature of bacillary dysentery. The ability is dependent on the interaction of VirG with neural Wiskott-Aldrich syndrome protein (N-WASP), which in turn mediates recruitment of Arp2/3 complex and several actin-related proteins. In the present study, we show that profilin I is essential to the rapid movement of Shigella in epithelial cells, for which the capacity of profilin to interact with G… CONTINUE READING