Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.

@article{Rotty2015Profilin1SA,
  title={Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.},
  author={Jeremy D. Rotty and Congying Wu and Elizabeth M. Haynes and Cristian Suarez and Jonathan D. Winkelman and Heath E. Johnson and Jason M. Haugh and David R Kovar and James E Bear},
  journal={Developmental cell},
  year={2015},
  volume={32 1},
  pages={54-67}
}
Cells contain multiple F-actin assembly pathways, including the Arp2/3 complex, formins, and Ena/VASP, which have largely been analyzed separately. They collectively generate the bulk of F-actin from a common pool of G-actin; however, the interplay and/or competition between these pathways remains poorly understood. Using fibroblast lines derived from an Arpc2 conditional knockout mouse, we established matched-pair cells with and without the Arp2/3 complex. Arpc2(-/-) cells lack lamellipodia… CONTINUE READING
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