Profilin-1 promotes the development of hypertension-induced cardiac hypertrophy.

  title={Profilin-1 promotes the development of hypertension-induced cardiac hypertrophy.},
  author={Shao-hua Zhao and Jie Qiu and Yan Wang and Xiang ‐ Fei Ji and Xiang-ju Liu and Bei-an You and Yu-ping Sheng and Xiao Li and Hai-qing Gao},
  journal={Journal of hypertension},
  volume={31 3},
  pages={576-86; discussion 586}
OBJECTIVE Cardiac hypertrophy is a major cause of heart failure and sudden cardiac death among hypertensive individuals. The present study examined the effects of profilin-1 on hypertension-induced cardiac hypertrophy. METHODS We used adenovirus injection to knockdown or overexpress profilin-1 in spontaneous hypertensive rats (SHRs). As a control, blank adenovirus was injected into age-matched SHRs and Wistar-Kyoto rats (WKYs). SBP and cardiac mass index were measured. Cardiac tissues were… CONTINUE READING
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