Profile of endothelial and leukocyte activation in Fabry patients.

  title={Profile of endothelial and leukocyte activation in Fabry patients.},
  author={Thomas DeGraba and Salman Azhar and Françoise Dignat-George and Ewan Brown and Brigitte Bouti{\`e}re and Gheona Altarescu and Richard McCarron and Raphael Schiffmann},
  journal={Annals of neurology},
  volume={47 2},
Fabry disease is an X-linked recessive disorder resulting in the deposition of globotriaosylceramide in numerous cell types including vascular endothelial cells. Because this disease is associated with vascular injury and a high recurrence rate of thrombotic events, measurements of factors regulating endothelium and leukocyte interaction may provide insight into the mechanisms leading to a prothrombotic state. Twenty-five patients with Fabry disease and 25 control subjects participated in the… CONTINUE READING