• DOI:10.1007/s12272-016-0727-7
Corpus ID: 19673707

Profile of disposition, tissue distribution and excretion of the novel anti-human immunodeficiency virus (HIV) agent W-1 in rats

@article{Lu2016ProfileOD,
  title={Profile of disposition, tissue distribution and excretion of the novel anti-human immunodeficiency virus (HIV) agent W-1 in rats},
  author={Y. Lu and X. Wang and Wenbing Dai and Q. Zhang and P. Li and Y. Lou and Chuang Lu and Jun-Yi Liu and G. Zhang},
  journal={Archives of Pharmacal Research},
  year={2016},
  volume={39},
  pages={970-977}
}

• Y. Lu, X. Wang, +7 authors G. Zhang
• Published 2016
• Chemistry, Medicine
• Archives of Pharmacal Research

The purpose of this study was to characterize the disposition, distribution, excretion and plasma protein binding of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1) in rats. Concentrations of W-1 within biological samples were determined using a validated high performance liquid chromatography method. The plasma protein binding of W-1 was examined by equilibrium dialysis method. After oral administration of W-1 (50, 100 and 200 mg/kg, respectively) in self-microemulsifying drug delivery system… Expand

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