Profile of circulating vasoactive substances in hemorrhagic shock and their pharmacologic manipulation.

@article{Jakschik1974ProfileOC,
  title={Profile of circulating vasoactive substances in hemorrhagic shock and their pharmacologic manipulation.},
  author={Barbara A. Jakschik and Garland R. Marshall and J L Kourik and Philip Needleman},
  journal={The Journal of clinical investigation},
  year={1974},
  volume={54 4},
  pages={842-52}
}
(a) Hemorrhage in dogs (to 45-50 mm Hg) was associated with a 10-fold increase in plasma renin activity (PRA) which remained elevated throughout the time-course of shock including the irreversible (decompensation) stage. The presence of angiotensin II (AII) in arterial blood was demonstrated by the bloodbathed organ technique and confirmed by blockade with… CONTINUE READING