Profile likelihood in systems biology.

@article{Kreutz2013ProfileLI,
  title={Profile likelihood in systems biology.},
  author={Clemens Kreutz and Andreas Raue and Daniel Kaschek and Jens Timmer},
  journal={The FEBS journal},
  year={2013},
  volume={280 11},
  pages={2564-71}
}
Inferring knowledge about biological processes by a mathematical description is a major characteristic of Systems Biology. To understand and predict system's behavior the available experimental information is translated into a mathematical model. Since the availability of experimental data is often limited and measurements contain noise, it is essential to appropriately translate experimental uncertainty to model parameters as well as to model predictions. This is especially important in… CONTINUE READING