Profile-based detection of microRNA precursors in animal genomes

@article{Legendre2005ProfilebasedDO,
  title={Profile-based detection of microRNA precursors in animal genomes},
  author={Matthieu Legendre and Andr{\'e} Lambert and Daniel Gautheret},
  journal={Bioinformatics},
  year={2005},
  volume={21 7},
  pages={841-5}
}
MOTIVATION MicroRNAs (miRNA) are essential 21-22 nt regulatory RNAs produced from larger hairpin-like precursors. Local sequence alignment tools such as BLAST are able to identify new members of known miRNA families, but not all of them. We set out to estimate how many new miRNAs could be recovered using a profile-based strategy such as that implemented in… CONTINUE READING