Profilaggrin is a major epidermal calcium-binding protein.

@article{Markova1993ProfilaggrinIA,
  title={Profilaggrin is a major epidermal calcium-binding protein.},
  author={Nedialka G. Markova and Lyuben N. Marekov and Constantin C. Chipev and Stoney Gan and William W. Idler and Peter M. Steinert},
  journal={Molecular and cellular biology},
  year={1993},
  volume={13 1},
  pages={
          613-25
        }
}
Profilaggrin is a major highly phosphorylated protein component of the keratohyalin granules of mammalian epidermis. It contains 10 to 12 tandemly repeated filaggrin units and is processed into the intermediate filament-associated protein filaggrin by specific dephosphorylation and proteolysis during terminal differentiation of the epidermal cells. Later, filaggrin itself is degraded to free amino acids that participate in maintenance of epidermal flexibility. The present paper describes the… CONTINUE READING

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