Profibrotic transforming growth factor beta 1 and activin A are increased in nasal polyp tissue and induced in nasal polyp epithelium by cigarette smoke and Toll-like receptor 3 ligation.

@article{Yamin2015ProfibroticTG,
  title={Profibrotic transforming growth factor beta 1 and activin A are increased in nasal polyp tissue and induced in nasal polyp epithelium by cigarette smoke and Toll-like receptor 3 ligation.},
  author={Moshe Yamin and Eric H. Holbrook and Stacey Tutt Gray and Nicolas Y. Busaba and Brooke Lovett and Daniel L. Hamilos},
  journal={International forum of allergy & rhinology},
  year={2015},
  volume={5 7},
  pages={573-82}
}
BACKGROUND The mechanism of airway remodeling in chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unknown. We wished to determine whether profibrotic transforming growth factor beta 1 (TGF-β1) and activin A and their downstream signaling proteins are increased in CRSwNP and if they are regulated in epithelial cells by noxious or inflammatory stimuli. METHODS Frozen tissue from CRSwNP patients, healthy control (HC) middle turbinates, and sinus tissue from CRS without NP (CRSsNP… CONTINUE READING
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