Profibrillin‐1 maturation by human dermal fibroblasts: Proteolytic processing and molecular chaperones

@article{Wallis2003Profibrillin1MB,
  title={Profibrillin‐1 maturation by human dermal fibroblasts: Proteolytic processing and molecular chaperones},
  author={D. Wallis and E. Putnam and Jill S Cretoiu and S. Carmical and S. Cao and G. Thomas and D. Milewicz},
  journal={Journal of Cellular Biochemistry},
  year={2003},
  volume={90}
}
Fibrillin‐1 is synthesized as a proprotein that undergoes proteolytic processing in the unique C‐terminal domain by a member of the PACE/furin family of endoproteases. This family of endoproteases is active in the trans‐Golgi network (TGN), but metabolic labeling studies have been controversial as to whether profibrillin‐1 is processed intracellularly or after secretion. This report provides evidence that profibrillin‐1 processing is not an intracellular event. Bafilomycin A1 and incubation of… Expand
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