Proestrous hormonal changes preceding the onset of ovulatory failure in lightly androgenized female rats.

@article{Handa1985ProestrousHC,
  title={Proestrous hormonal changes preceding the onset of ovulatory failure in lightly androgenized female rats.},
  author={Robert J. Handa and Thomas E. Nass and Roger A. Gorski},
  journal={Biology of reproduction},
  year={1985},
  volume={32 2},
  pages={
          232-40
        }
}
Proestrous hormonal profiles were characterized in lightly androgenized female rats prior to the onset of the delayed anovulatory syndrome (DAS). In these females, ovulatory failure and persistent vaginal estrus (PVE) occur at a very early age. Female Sprague-Dawley rats were injected with 10 micrograms testosterone propionate (TP) on postnatal Day 5. Control rats were untreated. All animals were weaned at 21 days of age, and following the onset of puberty, estrous cyclicity was monitored by… CONTINUE READING
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