Proestrous compared to diestrous wildtype, but not estrogen receptor beta knockout, mice have better performance in the spontaneous alternation and object recognition tasks and reduced anxiety-like behavior in the elevated plus and mirror maze.

@article{Walf2009ProestrousCT,
  title={Proestrous compared to diestrous wildtype, but not estrogen receptor beta knockout, mice have better performance in the spontaneous alternation and object recognition tasks and reduced anxiety-like behavior in the elevated plus and mirror maze.},
  author={Alicia A. Walf and Carolyn J. Koonce and Kevin Manley and Cheryl Anne Frye},
  journal={Behavioural brain research},
  year={2009},
  volume={196 2},
  pages={254-60}
}
17beta-Estradiol (E(2)) may influence cognitive and/or affective behavior in part via the beta isoform of the estrogen receptor (ERbeta). Endocrine status and behavior in cognitive (object recognition, T-maze), anxiety (open field, elevated plus maze, mirror maze, emergence), and motor/coordination (rotarod, activity chamber) tasks of proestrous and diestrous wildtype (WT) and ERbeta knockout (betaERKO) mice was examined. Proestrous (WT or betaERKO), versus diestrous, mice had higher E(2) and… CONTINUE READING
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