Proenzyme psa for the early detection of prostate cancer in the 2.5-4.0 ng/ml total psa range: preliminary analysis.

@article{Sokoll2003ProenzymePF,
  title={Proenzyme psa for the early detection of prostate cancer in the 2.5-4.0 ng/ml total psa range: preliminary analysis.},
  author={Lori Sokoll and Daniel Wai-Tin Chan and Stephen D. Mikolajczyk and Harry G. Rittenhouse and Cindy L. Evans and Harry J Linton and Leslie A. Mangold and Phaedre Mohr and Georg Bartsch and Helmut Klocker and Wolfgang Horninger and Alan W. Partin},
  journal={Urology},
  year={2003},
  volume={61 2},
  pages={274-6}
}
OBJECTIVES To determine the clinical utility of using proenzyme prostate-specific antigen (pPSA) for early detection of prostate cancer in the 2.5 to 4.0 ng/mL total PSA range. pPSA, the precursor form of PSA that contains a 7 amino acid leader peptide, and truncated forms such as [-2]pPSA and [-4]pPSA can be measured in serum by research immunoassay. METHODS Archival serum from 119 men (noncancer, 88; cancer, 31), obtained before biopsy and in the total PSA range of 2.5 to 4.0 ng/mL, were… CONTINUE READING
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