Products of the grg (Groucho-related gene) family can dimerize through the amino-terminal Q domain.

@article{Pinto1996ProductsOT,
  title={Products of the grg (Groucho-related gene) family can dimerize through the amino-terminal Q domain.},
  author={Martha L. Pinto and Corrinne G. Lobe},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 51},
  pages={33026-31}
}
The murine grg (Groucho-related gene) products are believed to interact with transcription factors and repress transcription, thereby regulating cell proliferation and differentiation. Most proteins in the grg family contain all of the domains found in the Drosophila Groucho protein, including the S/P (Ser-Pro-rich) domain required for interaction with transcription factors and the WD40 domain, which is thought to interact with other proteins. However, at least two Grg proteins contain only the… CONTINUE READING