Products of the colonic microbiota mediate the effects of diet on colon cancer risk.

@article{Okeefe2009ProductsOT,
  title={Products of the colonic microbiota mediate the effects of diet on colon cancer risk.},
  author={Stephen J D O'keefe and Junhai Ou and Susanne Aufreiter and Deborah L O'Connor and Sumit Sharma and Jorge Gonz{\'a}lez Sep{\'u}lveda and Tsutomu Fukuwatari and Katsumi Shibata and Thomas P. Mawhinney},
  journal={The Journal of nutrition},
  year={2009},
  volume={139 11},
  pages={2044-8}
}
It is estimated that most colon cancers can be attributed to dietary causes. We have hypothesized that diet influences the health of the colonic mucosa through interaction with the microbiota and that it is the milieu interior that regulates mucosal proliferation and therefore cancer risk. To validate this further, we compared colonic contents from healthy 50- to 65-y-old people from populations with high and low risk, specifically low risk Native Africans (cancer incidence <1:100,000; n = 17… CONTINUE READING
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