Products of hemolysis in the subarachnoid space inducing spreading ischemia in the cortex and focal necrosis in rats: a model for delayed ischemic neurological deficits after subarachnoid hemorrhage?

@article{Dreier2000ProductsOH,
  title={Products of hemolysis in the subarachnoid space inducing spreading ischemia in the cortex and focal necrosis in rats: a model for delayed ischemic neurological deficits after subarachnoid hemorrhage?},
  author={Jens P Dreier and Norbert Ebert and Josef Priller and Dirk Megow and Ute Lindauer and Rolf Klee and Uwe Reuter and Yutaka Imai and KarlM. Einh{\"a}upl and Ilya V. Victorov and Ulrich Dirnagl},
  journal={Journal of neurosurgery},
  year={2000},
  volume={93 4},
  pages={
          658-66
        }
}
OBJECT The pathogenesis of delayed ischemic neurological deficits after subarachnoid hemorrhage has been related to products of hemolysis. Topical brain superfusion of artificial cerebrospinal fluid (ACSF) containing the hemolysis products K+ and hemoglobin (Hb) was previously shown to induce ischemia in rats. Superimposed on a slow vasospastic reaction, the ischemic events represent spreading depolarizations of the neuronal-glial network that trigger acute vasoconstriction. The purpose of the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 99 CITATIONS

Neuroprotective Role of the Nrf2 Pathway in Subarachnoid Haemorrhage and Its Therapeutic Potential

  • Oxidative medicine and cellular longevity
  • 2019
VIEW 9 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The Stroke-Migraine Depolarization Continuum

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2002
2019

CITATION STATISTICS

  • 9 Highly Influenced Citations

  • Averaged 6 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 52 REFERENCES

Nitric oxide and glutamate interaction in the control of cortical and hippocampal excitability

G Ferraro, ME Montalbano, V La Grutta
  • Epilepsia 40:830–836,
  • 1999

Lanksch WR: Bedside-microdialysis for early detection of vasospasm after subarachnoid hemorrhage. Case report and review of the literature

AS Sarrafzadeh, AW Unterberg
  • Zentralbl Neurochir 59:269–273,
  • 1998

Nitric oxide scavenging by hemoglobin or nitric oxide synthase inhibition by N-nitro-L-arginine induces cortical spreading ischemia when K+ is increased in the subarachnoid space.

  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1998

The ischemic penumbra: pathophysiology, and relevance of spreading depression-like phenomena, in Ginsberg MD, Bogousslavsky J (eds): Cerebrovascular Disease. Pathophysiology, Diagnosis, and Treatment

T Back, M Nedergaard, MD Ginsberg
  • 1998

Neuropathology of subarachnoid hemorrhage, in Bederson JB (ed): Subarachnoid Hemorrhage: Pathophysiology and Management

G Stoltenburg-Didinger
  • Park Ridge, IL: American Association of Neurological Surgeons,
  • 1997

Similar Papers

Loading similar papers…