Products of hemolysis in the subarachnoid space inducing spreading ischemia in the cortex and focal necrosis in rats: a model for delayed ischemic neurological deficits after subarachnoid hemorrhage?

@article{Dreier2000ProductsOH,
  title={Products of hemolysis in the subarachnoid space inducing spreading ischemia in the cortex and focal necrosis in rats: a model for delayed ischemic neurological deficits after subarachnoid hemorrhage?},
  author={Jens P Dreier and Norbert Ebert and Josef Priller and Dirk Megow and Ute Lindauer and Rolf Klee and Uwe Reuter and Yutaka Imai and KarlM. Einh{\"a}upl and Ilya V. Victorov and Ulrich Dirnagl},
  journal={Journal of neurosurgery},
  year={2000},
  volume={93 4},
  pages={
          658-66
        }
}
OBJECT The pathogenesis of delayed ischemic neurological deficits after subarachnoid hemorrhage has been related to products of hemolysis. Topical brain superfusion of artificial cerebrospinal fluid (ACSF) containing the hemolysis products K+ and hemoglobin (Hb) was previously shown to induce ischemia in rats. Superimposed on a slow vasospastic reaction, the ischemic events represent spreading depolarizations of the neuronal-glial network that trigger acute vasoconstriction. The purpose of the… CONTINUE READING

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