Productive replication of nephropathogenic infectious bronchitis virus in peripheral blood monocytic cells, a strategy for viral dissemination and kidney infection in chickens

@inproceedings{Reddy2016ProductiveRO,
  title={Productive replication of nephropathogenic infectious bronchitis virus in peripheral blood monocytic cells, a strategy for viral dissemination and kidney infection in chickens},
  author={Vishwanatha R. A. P. Reddy and Ivan Trus and Lowiese M. B. Desmarets and Yewei Li and Sebastiaan Theuns and Hans J Nauwynck},
  booktitle={Veterinary Research},
  year={2016}
}
In the present study, the replication kinetics of nephropathogenic (B1648) and respiratory (Massachusetts-M41) IBV strains were compared in vitro in respiratory mucosa explants and blood monocytes (KUL01+ cells), and in vivo in chickens to understand why some IBV strains have a kidney tropism. B1648 was replicating somewhat better than M41 in the epithelium of the respiratory mucosa explants and used more KUL01+ cells to penetrate the deeper layers of the respiratory tract. B1648 was… CONTINUE READING
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