Productive replication of Vif-chimeric HIV-1 in feline cells.

  title={Productive replication of Vif-chimeric HIV-1 in feline cells.},
  author={Melissa A Stern and Chunling Hu and Dyana T. Saenz and Hind J. Fadel and Olivia L. Sims and Mary Peretz and Eric M. Poeschla},
  journal={Journal of virology},
  volume={84 14},
Nonprimate animal models of HIV-1 infection are prevented by missing cellular cofactors and by antiviral actions of species-specific host defense factors. These blocks are profound in rodents but may be less abundant in certain Carnivora. Here, we enabled productive, spreading replication and passage of HIV-1 in feline cells. Feline fibroblasts, T-cell lines, and primary peripheral blood mononuclear cells supported early and late HIV-1 life cycle phases in a manner equivalent to that of human… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 26 extracted citations

Vif determines the requirement for CBF-β in APOBEC3 degradation.

The Journal of general virology • 2015
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…