Productive Infection of Neonatal CD8+ T Lymphocytes by HIV-1

  title={Productive Infection of Neonatal CD8+ T Lymphocytes by HIV-1 },
  author={Liang Peng Yang and James L Riley and Richard G Carroll and Carl H June and James A Hoxie and Bruce K. Patterson and Yusei Ohshima and Richard J Hodes and Guy Delespesse},
  journal={The Journal of Experimental Medicine},
  pages={1139 - 1144}
CD8+ T lymphocytes confer significant but ultimately insufficient protection against HIV infection. Here we report that activated neonatal CD8+ T cells can be productively infected in vitro by macrophage-tropic (M-tropic) HIV-1 isolates, which are responsible for disease transmission, whereas they are resistant to T cell-tropic (T-tropic) HIV strains. Physiological activation of CD8-alpha/beta+ CD4- T cell receptor-alpha/beta+ neonatal T cells, including activation by allogeneic dendritic cells… CONTINUE READING