Productive Homologous and Non-homologous Recombination of Hepatitis C Virus in Cell Culture

@inproceedings{Scheel2013ProductiveHA,
  title={Productive Homologous and Non-homologous Recombination of Hepatitis C Virus in Cell Culture},
  author={Troels K H Scheel and Andrea Galli and Yi-Ping Li and Lotte S. Mikkelsen and Judith M. Gottwein and Jens Bukh},
  booktitle={PLoS pathogens},
  year={2013}
}
Genetic recombination is an important mechanism for increasing diversity of RNA viruses, and constitutes a viral escape mechanism to host immune responses and to treatment with antiviral compounds. Although rare, epidemiologically important hepatitis C virus (HCV) recombinants have been reported. In addition, recombination is an important regulatory mechanism of cytopathogenicity for the related pestiviruses. Here we describe recombination of HCV RNA in cell culture leading to production of… CONTINUE READING
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