Production of type VI collagen by human macrophages: a new dimension in macrophage functional heterogeneity.

@article{Schnoor2008ProductionOT,
  title={Production of type VI collagen by human macrophages: a new dimension in macrophage functional heterogeneity.},
  author={Michael Schnoor and Paul Cullen and Julia Lorkowski and Katrin Stolle and Horst Robenek and David Troyer and J. Rauterberg and Stefan Lorkowski},
  journal={Journal of immunology},
  year={2008},
  volume={180 8},
  pages={5707-19}
}
Macrophages derived from human blood monocytes perform many tasks related to tissue injury and repair. The main effect of macrophages on the extracellular matrix is considered to be destructive in nature, because macrophages secrete metalloproteinases and ingest foreign material as part of the remodeling process that occurs in wound healing and other pathological conditions. However, macrophages also contribute to the extracellular matrix and hence to tissue stabilization both indirectly, by… CONTINUE READING
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