Production of tumor necrosis factor-alpha by B-cell chronic lymphocytic leukemia cells: a possible regulatory role of TNF in the progression of the disease.

@article{Fo1990ProductionOT,
  title={Production of tumor necrosis factor-alpha by B-cell chronic lymphocytic leukemia cells: a possible regulatory role of TNF in the progression of the disease.},
  author={Robin Fo{\'a} and Massimo Massaia and Servando Cardona and Anna Gillio Tos and A V Bianchi and C Attisano and Anna Rita Guarini and Paola Francia di Celle and Mar{\'i}a T Fierro},
  journal={Blood},
  year={1990},
  volume={76 2},
  pages={393-400}
}
Tumor necrosis factor-alpha (TNF) is a cytokine that displays a pleomorphic array of effects on different cell populations. Evidence is presented that TNF may be constitutively produced by B-cell chronic lymphocytic leukemia (B-CLL) and hairy cell leukemia (HCL) cells and that it may play a relevant role in these diseases. These conclusions are based on the presence of circulating levels of TNF in the serum of 20 of the 24 patients tested (83.3%), while undetectable values were found in normal… CONTINUE READING
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Tumor necrosis factor induces proliferation of neoplastic B cells from chronic lymphocytic leuke

  • E Klein, G Klein, JS Nadkarni, JJ Nadkarni, H Wigzell, P Clifford
  • Blood
  • 1989

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