Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth

  title={Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth},
  author={John H. Kehrl and Lalage M. Wakefield and Anita B. Roberts and Sonia B. Jakowlew and Melchor {\'A}lvarez-Mon and Rik Derynck and Michael B. Sporn and Anthony S. Fauci},
  journal={The Journal of Experimental Medicine},
  pages={1037 - 1050}
This study examines the potential role of transforming growth factor beta (TGF-beta) in the regulation of human T lymphocyte proliferation, and proposes that TGF-beta is an important autoregulatory lymphokine that limits T lymphocyte clonal expansion, and that TGF-beta production by T lymphocytes is important in T cell interactions with other cell types. TGF-beta was shown to inhibit IL-2-dependent T cell proliferation. The addition of picograms amounts of TGF-beta to cultures of IL-2… 

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  • A. RobertsM. Sporn J. Kehrl
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    Proceedings of the National Academy of Sciences of the United States of America
  • 1986
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