Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth

@article{Kehrl1986ProductionOT,
  title={Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth},
  author={J. Kehrl and L. Wakefield and A. Roberts and S. Jakowlew and M. {\'A}lvarez-Mon and R. Derynck and M. Sporn and A. Fauci},
  journal={The Journal of Experimental Medicine},
  year={1986},
  volume={163},
  pages={1037 - 1050}
}
This study examines the potential role of transforming growth factor beta (TGF-beta) in the regulation of human T lymphocyte proliferation, and proposes that TGF-beta is an important autoregulatory lymphokine that limits T lymphocyte clonal expansion, and that TGF-beta production by T lymphocytes is important in T cell interactions with other cell types. TGF-beta was shown to inhibit IL-2-dependent T cell proliferation. The addition of picograms amounts of TGF-beta to cultures of IL-2… Expand
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  • A. Roberts, M. Sporn, +7 authors J. Kehrl
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1986
TLDR
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