Production of the lantibiotic salivaricin A and its variants by oral streptococci and use of a specific induction assay to detect their presence in human saliva.

@article{Wescombe2006ProductionOT,
  title={Production of the lantibiotic salivaricin A and its variants by oral streptococci and use of a specific induction assay to detect their presence in human saliva.},
  author={Philip A. Wescombe and M. A. G. Upton and Karen P. Dierksen and Nancy L. Ragland and Senthuran Sivabalan and Ruth E. Wirawan and Megan A. Inglis and Chris J. Moore and Glenn Vincent Walker and Chris Chilcott and Howard F Jenkinson and John Robert Tagg},
  journal={Applied and environmental microbiology},
  year={2006},
  volume={72 2},
  pages={
          1459-66
        }
}
Salivaricin A (SalA), the first Streptococcus salivarius lantibiotic to be characterized, appears to be inhibitory to most Streptococcus pyogenes strains. A variant of the SalA structural gene (salA1) is present in more than 90% of S. pyogenes strains, but only strains of M serotype 4 and T pattern 4 produce the biologically active peptide. The present study identifies four additional variants (salA2 to salA5) of the SalA structural gene and demonstrates that each of the corresponding… CONTINUE READING

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