Production of taxadiene from cultured ginseng roots transformed with taxadiene synthase gene.

@article{Cha2012ProductionOT,
  title={Production of taxadiene from cultured ginseng roots transformed with taxadiene synthase gene.},
  author={Mijeong Cha and Sang Hee Shim and Sung Sun Kim and Ok Tae Kim and Se-Weon Lee and Suk Yoon Kwon and Kwang Hyun Baek},
  journal={BMB reports},
  year={2012},
  volume={45 10},
  pages={589-94}
}
Paclitaxel is produced by various species of yew trees and has been extensively used to treat tumors. In our research, a taxadiene synthase (TS) gene from Taxus brevifolia was used to transform the roots of cultured ginseng (Panax ginseng C.A. Meyer) to produce taxadiene, the unique skeletal precursor to taxol. The TS gene was successfully introduced into the ginseng genome, and the de novo formation of taxadiene was identified by mass spectroscopy profiling. Without any change in phenotypes or… CONTINUE READING