Production of sophorolipids with enhanced volumetric productivity by means of high cell density fermentation

@article{Gao2012ProductionOS,
  title={Production of sophorolipids with enhanced volumetric productivity by means of high cell density fermentation},
  author={Renjun Gao and Mia Fiils\oe Falkeborg and Xuebing Xu and Zheng Xiao Guo},
  journal={Applied Microbiology and Biotechnology},
  year={2012},
  volume={97},
  pages={1103-1111}
}
To achieve high time–space efficiency for sophorolipid production with yeast Candida bombicola, a strategy of high cell density fermentation was employed. The approach consisted of two sequential stages: (1) the optimization of the carbon source and the nutrient concentration to achieve the maximal cell density and (2) the computer-aided adjustment of physical parameters and the controlled feeding of substrates for enhanced volumetric productivity. Both stages have been successfully implemented… CONTINUE READING

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